Phenols In Olive Oil Affect Genes That Control Inflammation, Heart Disease

June 28, 2010: 03:19 PM EST

Phenols in olive oil have been found to modify genes involved in the inflammatory response associated with heart disease, according to researchers who studied the effects of olive oil consumption on people with metabolic syndrome and at high risk for heart disease and diabetes. The volunteers were all fed the same low-fat, carbohydrate-rich diet and virgin olive oil breakfasts with either high-content phenolic compounds or low-content phenolic compounds. About 15,000 genes were tracked; 79 were turned down and 19 turned up by the high-phenolic-content olive oil. The researchers said the results shed light on the molecular basis for reduced heart disease risk in Mediterranean countries where virgin olive oil is the main source of dietary fats.

Antonio Camargo, Juan Ruano, Francisco Perez-Jimenez, Laurence Parnell, et al. , "Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil", Biomed Central (BMC) Genomics, June 28, 2010, © Camargo, et al.

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